Keratinocyte hyperproliferation and shortened cell cycles are important pathophysiological features of psoriasis as a known oncogene yes associated protein yap plays a role in promoting cell proliferation and inhibiting cell apoptosis however whether yap is involved in the pathogenesis of psoriasis remains to be determined. Psoriasis is a skin disease characterized by hyperproliferation of keratinocytes and chronic inflammation mesenchymal stem stromal cells mscs exhibit an immunoregulatory function that can be altered in the skin of these patients. psoriasis cell proliferation uploaded by r l stine psoriasis is a common chronic inflammatory skin disorder affecting 1 2 of the northern american and european populations it has characteristic hitological changes including epidermal hyperproliferation infiltration of t cells and dendritic cells and a distinct increase in skin. Psoriasis is mediated primarily by t cells which reduce epidermal turnover time and affect keratinocyte proliferation we aimed to identify differentially expressed genes deg in t cells from normal five pairs of monozygotic twins concordant or discordant for psoriasis to determine whether these deg may account for the influence to epidermal
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